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ScientificWorldJournal. 2012;2012:627607. doi: 10.1100/2012/627607. Epub 2012 May 2.

Simultaneous determination of parathion, malathion, diazinon, and pirimiphos methyl in dried medicinal plants using solid-phase microextraction fibre coated with single-walled carbon nanotubes.

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  • 1Pharmaceutical Sciences Research Center, Tehran University of Medical Sciences, Tehran 14174, Iran.


A reliable and sensitive headspace solid-phase microextraction gas chromatography-mass spectrometry method for simultaneous determination of different organophosphorus pesticides in dried medicinal plant samples is described. The analytes were extracted by single-walled carbon nanotubes as a new solid-phase microextraction adsorbent. The developed method showed good performance. For diazinon and pirimiphos methyl calibration, curves were linear (r(2) ≥ 0.993) over the concentration ranges from 1.5 to 300 ng g(-1), and the limit of detection at signal-to-noise ratio of 3 was 0.3 ng g(-1). For parathion and malathion, the linear range and limit of detection were 2.5-300 (r(2) ≥ 0.991) and 0.5 ng g(-1), respectively. In addition, a comparative study between the single-walled carbon nanotubes and a commercial polydimethylsiloxane fibre for the determination of target analytes was carried out. Single-walled carbon nanotubes fibre showed higher extraction capacity, better thermal stability (over 350 °C), and longer lifespan (over 250 times) than the commercial polydimethylsiloxane fibre. The developed method was successfully applied to determine target organophosphorus pesticides in real samples.

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