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Semin Cutan Med Surg. 2012 Jun;31(2):140-9. doi: 10.1016/j.sder.2012.03.002.

Cutting edge in medical management of cutaneous oncology.

Author information

  • 1Department of Dermatology, University of California at San Francisco, San Francisco, CA 94143, USA. arrons@derm.ucsf.edu

Abstract

Traditional chemotherapy has resulted in only a modest response, if any, for the 3 most common cutaneous malignancies of basal cell carcinoma, squamous cell carcinoma, and melanoma. Recent advances in understanding of the defects in the pathways driving tumorigenesis have changed the way that we think of these cancers and paved the way to targeted therapy for specific tumors. In this review, we will introduce the novel systemic treatments currently available for these cancers in the context of what is understood about the tumor pathogenesis. We will also introduce ongoing studies that will hopefully broaden our options for highly effective and tolerable treatment.

Copyright © 2012 Elsevier Inc. All rights reserved.

PMID:
22640435
[PubMed - indexed for MEDLINE]
PMCID:
PMC3367308
Free PMC Article

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