BDNF -270 C>T polymorphisms might be associated with stroke type and BDNF -196 G>A corresponds to early neurological deficit in hemorrhagic stroke

J Neuroimmunol. 2012 Aug 15;249(1-2):71-5. doi: 10.1016/j.jneuroim.2012.04.011. Epub 2012 May 24.

Abstract

Genetic factors might be involved in stroke prognosis, however the role of brain-derived neurotrophic factor (BDNF) in stroke recovery is unknown. We have studied BDNF -196 G>A and -270 C>T polymorphisms in ischemic and hemorrhagic stroke and their impact on stroke prognosis. There was higher occurrence of BDNF -270 CC genotype in patients with hemorrhagic than ischemic stroke (96% versus 86%, p=0.0495). In hemorrhagic stroke BDNF -196 GG carriers scored better in NIHSS at admission (14.23 versus 21.00, p=0.0192) and after 7days (8.60 versus 15.00, p=0.0408) of onsets. None of the determined polymorphisms had any impact on 30-day early outcome in ischemic and hemorrhagic stroke.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Aged
  • Brain Ischemia / complications
  • Brain Ischemia / genetics*
  • Brain-Derived Neurotrophic Factor / genetics*
  • Female
  • Genetic Predisposition to Disease / genetics
  • Genotype
  • Humans
  • Intracranial Hemorrhages / complications
  • Intracranial Hemorrhages / genetics*
  • Male
  • Polymerase Chain Reaction
  • Polymorphism, Restriction Fragment Length*
  • Prognosis
  • Recovery of Function / genetics*
  • Stroke / etiology
  • Stroke / genetics*

Substances

  • Brain-Derived Neurotrophic Factor