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Infect Dis Clin North Am. 2012 Jun;26(2):479-96. doi: 10.1016/j.idc.2012.02.003. Epub 2012 Apr 17.

Arboviruses and viral hemorrhagic fevers (VHF).

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  • 1Department of Medicine C, Sheba Medical Center, Center for Geographic Medicine, Tel Hashomer 52621, Israel.


The viral hemorrhagic fever (VHF) syndrome is a potentially life-threatening infection typified by a combination of a capillary leak syndrome and bleeding diathesis. Most but not all agents causing VHF are arboviruses, with transmission to humans resulting from an arthropod bite. Agents of VHF affect humans on all continents. Population growth, urbanization, human activities, and even climate change all contribute to a continual flux in the epidemiology of many arboviruses. This review provides an overview of the epidemiology of arboviral infections and VHF, the main clinical syndromes, and their diagnosis and treatment.

Copyright © 2012 Elsevier Inc. All rights reserved.

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