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Front Genet. 2012 May 17;3:82. doi: 10.3389/fgene.2012.00082. eCollection 2012.

The Path to microRNA Therapeutics in Psychiatric and Neurodegenerative Disorders.

Author information

  • 1Yerkes National Primate Research Center Atlanta, GA, USA.

Abstract

The microRNA (miRNA) class of non-coding RNAs exhibit a diverse range of regulatory roles in neuronal functions that are conserved from lower vertebrates to primates. Disruption of miRNA expression has compellingly been linked to pathogenesis in neuropsychiatric and neurodegenerative disorders, such as schizophrenia, Alzheimer's disease, and autism. The list of transcript targets governed by a single miRNA provide a molecular paradigm applicable for therapeutic intervention. Indeed, reports have shown that specific manipulation of a miRNA in cell or animal models can significantly alter phenotypes linked with neurological disease. Here, we review how a diverse range of biological systems, including Drosophila, rodents, and primates such as monkeys and humans, can be integrated into the translation of miRNAs as novel clinical targets.

KEYWORDS:

microRNAs; monkeys; neurodegeneration; non-coding RNA; primates; psychiatric; schizophrenia; therapeutics

PMID:
22629284
[PubMed]
PMCID:
PMC3354561
Free PMC Article
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