Display Settings:

Format

Send to:

Choose Destination
See comment in PubMed Commons below
Science. 2012 May 25;336(6084):1040-4. doi: 10.1126/science.1218595.

Metabolite profiling identifies a key role for glycine in rapid cancer cell proliferation.

Author information

  • 1Broad Institute, Cambridge, MA 02142, USA.

Abstract

Metabolic reprogramming has been proposed to be a hallmark of cancer, yet a systematic characterization of the metabolic pathways active in transformed cells is currently lacking. Using mass spectrometry, we measured the consumption and release (CORE) profiles of 219 metabolites from media across the NCI-60 cancer cell lines, and integrated these data with a preexisting atlas of gene expression. This analysis identified glycine consumption and expression of the mitochondrial glycine biosynthetic pathway as strongly correlated with rates of proliferation across cancer cells. Antagonizing glycine uptake and its mitochondrial biosynthesis preferentially impaired rapidly proliferating cells. Moreover, higher expression of this pathway was associated with greater mortality in breast cancer patients. Increased reliance on glycine may represent a metabolic vulnerability for selectively targeting rapid cancer cell proliferation.

Comment in

PMID:
22628656
[PubMed - indexed for MEDLINE]
PMCID:
PMC3526189
Free PMC Article
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for HighWire Icon for PubMed Central
    Loading ...
    Write to the Help Desk