Display Settings:

Format

Send to:

Choose Destination
See comment in PubMed Commons below
Turk Patoloji Derg. 2012;28(2):134-41. doi: 10.5146/tjpath.2012.01112.

Metaplastic breast carcinomas and their relationship with basal-like phenotype.

Author information

  • 1Department of Pathology, Gazi University, Faculty of Medicine, Ankara, Turkey. erdoganasli@gmail.com

Abstract

OBJECTIVE:

Metaplastic carcinoma is a rare tumor showing high histological grade and low hormone receptor expression. It has pure epithelial and mixed types. Studies have suggested that metaplastic carcinomas may have a basal-like profile. Our aim was to evaluate the clinicopathological features of 11 metaplastic carcinomas and determine their resemblance to basal-like breast carcinomas regarding their morphological and immunohistochemical profile.

MATERIAL AND METHOD:

Eleven metaplastic carcinoma cases were reviewed for their histopathological features. All tumors but one were evaluated for the immunohistochemical expressions of the cytokeratin 5/6, cytokeratin 14 and epidermal growth factor receptor; and hormonal status was assessed.

RESULTS:

Four of eleven cases were carcinoma with chondroid metaplasia, 3 were adenosquamous carcinoma, 2 were squamous cell carcinoma and 2 were carcinosarcoma. The mean patient age was 53 years and the mean tumor size was 5,1 cm. Histological grade was 3 for all with a nuclear grade of 3. Average mitotic count was 31/10 high power fields. Four cases had a central scar, 5 had central necrosis and 7 had geographic necrosis. Tumor growth pattern was pushing in 6 cases and no carcinoma in-situ was identified in 5 cases. Seven of 10 patients had axillary lymph node metastasis. Seven of 10 cases were triple-negative (estrogen receptor-, progesterone receptor-, HER2-) and 6 of them were positive for cytokeratin 5/6 and/or epidermal growth factor receptor, consistent with basal-like immunophenotype. Cytokeratin 14 was positive in 7 cases.

CONCLUSION:

Metaplastic carcinomas are large-sized, high-grade tumors with prominent nuclear pleomorphism and frequent mitosis. They rarely overexpress hormone receptors and HER2 and generally have basal-like immunophenotype.

PMID:
22627631
[PubMed - indexed for MEDLINE]
Free full text
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Turkish Journal of Pathology
    Loading ...
    Write to the Help Desk