Cancer Lett. 2012 Nov 28;324(2):119-25. doi: 10.1016/j.canlet.2012.05.012. Epub 2012 May 21.

Green tea: an effective synergist with anticancer drugs for tertiary cancer prevention.

Source

Faculty of Pharmaceutical Sciences, Tokushima Bunri University, Tokushima 770-8514, Japan. hfujiki@ph.bunri-u.ac.jp

Abstract

Green tea is now an acknowledged cancer preventive in Japan. Based on evidence that colorectal adenomas and prostate cancer in humans have been prevented, we review here the concept that the combination of anticancer drugs with green tea catechin synergistically induces apoptosis of human cancer cells, inhibits tumor formation in mice, and enhances inhibition of tumor growth in xenograft mouse models. As a molecular mechanism by the combination, the induction of growth arrest and DNA damage-inducible 153 (GADD153, CHOP) gene expression is discussed in relation to death receptor 5 and TRAIL-apoptotic pathway. The combination of anticancer drugs with green tea could be a new cancer therapeutic strategy in humans.

PMID:: 22626556; [PubMed - indexed for MEDLINE]

Publication Types, MeSH Terms, Substances

Publication Types

Review

MeSH Terms

Substances

LinkOut - more resources

Full Text Sources

Other Literature Sources

Labome Researcher Resource - ExactAntigen/Labome

Medical

Miscellaneous

Supplemental Content

Save items

Related citations in PubMed

Review New cancer treatment strategy using combination of green tea catechins and anticancer drugs. [Cancer Sci. 2011]
Review New cancer treatment strategy using combination of green tea catechins and anticancer drugs.
Suganuma M, Saha A, Fujiki H. Cancer Sci. 2011 Feb; 102(2):317-23. Epub 2010 Dec 30.
Green tea polyphenol stimulates cancer preventive effects of celecoxib in human lung cancer cells by upregulation of GADD153 gene. [Int J Cancer. 2006]
Green tea polyphenol stimulates cancer preventive effects of celecoxib in human lung cancer cells by upregulation of GADD153 gene.
Suganuma M, Kurusu M, Suzuki K, Tasaki E, Fujiki H. Int J Cancer. 2006 Jul 1; 119(1):33-40.
Prediction of proapoptotic anticancer therapeutic response in vivo based on cell death visualization and TRAIL death ligand-receptor interaction. [Cancer Biol Ther. 2011]
Prediction of proapoptotic anticancer therapeutic response in vivo based on cell death visualization and TRAIL death ligand-receptor interaction.
Zhou L, Wang W, Dicker DT, Humphreys RC, El-Deiry WS. Cancer Biol Ther. 2011 Aug 15; 12(4):335-48. Epub 2011 Aug 15.
New role of (-)-epicatechin in enhancing the induction of growth inhibition and apoptosis in human lung cancer cells by curcumin. [Cancer Prev Res (Phila). 2010]
New role of (-)-epicatechin in enhancing the induction of growth inhibition and apoptosis in human lung cancer cells by curcumin.
Saha A, Kuzuhara T, Echigo N, Suganuma M, Fujiki H. Cancer Prev Res (Phila). 2010 Aug; 3(8):953-62. Epub 2010 Jul 6.
Review The TRAIL apoptotic pathway in cancer onset, progression and therapy. [Nat Rev Cancer. 2008]
Review The TRAIL apoptotic pathway in cancer onset, progression and therapy.
Johnstone RW, Frew AJ, Smyth MJ. Nat Rev Cancer. 2008 Oct; 8(10):782-98.

See reviews... See all...

Cited by 1 PubMed Central article

Epigallocatechin Gallate (EGCG) is the most effective cancer chemopreventive polyphenol in green tea. [Nutrients. 2012]
Epigallocatechin Gallate (EGCG) is the most effective cancer chemopreventive polyphenol in green tea.
Du GJ, Zhang Z, Wen XD, Yu C, Calway T, Yuan CS, Wang CZ. Nutrients. 2012 Nov 8; 4(11):1679-91. Epub 2012 Nov 8.

Related information

Related Citations
Calculated set of PubMed citations closely related to the selected article(s) retrieved using a word weight algorithm. Related articles are displayed in ranked order from most to least relevant, with the “linked from” citation displayed first.
Compound (MeSH Keyword)
PubChem chemical compound records that are classified under the same Medical Subject Headings (MeSH) controlled vocabulary as the current articles.
MedGen
Related information in MedGen
Substance (MeSH Keyword)
PubChem chemical substance (submitted) records that are classified under the same Medical Subject Headings (MeSH) controlled vocabulary as the current articles.
Cited in PMC
Full-text articles in the PubMed Central Database that cite the current articles.

Recent activity

Clear Turn Off Turn On

Green tea: an effective synergist with anticancer drugs for tertiary cancer prev...
Green tea: an effective synergist with anticancer drugs for tertiary cancer prevention.
Cancer Lett. 2012 Nov 28 ;324(2):119-25. doi: 10.1016/j.canlet.2012.05.012. Epub 2012 May 21 .

PubMed

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

PubMed

Result Filters

Display Settings:

Send to: