DNA replication: Pif1 pulls the plug on stalled replication forks

Kenji Shimada; Susan M Gasser

doi:10.1016/j.cub.2012.04.015

DNA replication: Pif1 pulls the plug on stalled replication forks

Curr Biol. 2012 May 22;22(10):R404-5. doi: 10.1016/j.cub.2012.04.015.

Authors

Kenji Shimada¹, Susan M Gasser

Affiliation

¹ Friedrich Miescher Institute for Biomedical Research, Basel, Switzerland. kenji.shimada@fmi.ch

PMID: 22625857
DOI: 10.1016/j.cub.2012.04.015

Abstract

The conserved PIF helicase family appears to function in replication to ensure termination and passage through regions that slow or arrest replication fork movement. Findings in fission yeast extend evidence from budding yeast, and argue for universal mechanisms that ensure replication integrity.

MeSH terms

DNA Helicases / physiology*
DNA Replication / physiology*
Saccharomyces cerevisiae / physiology*
Saccharomyces cerevisiae Proteins / physiology*
Schizosaccharomyces / physiology*
Schizosaccharomyces pombe Proteins / physiology*

Substances

Saccharomyces cerevisiae Proteins
Schizosaccharomyces pombe Proteins
PIF1 protein, S cerevisiae
DNA Helicases
Pfh1 protein, S pombe