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N Am J Med Sci. 2010 Feb;2(2):81-6. doi: 10.4297/najms.2010.281.

Effect of curcumin on quinpirole induced compulsive checking: An approach to determine the predictive and construct validity of the model.

Author information

  • 1Department of Pharmacology, Bapatla College of Pharmacy, Bapatla, Andhra Pradesh, India - 522101.

Abstract

BACKGROUND:

Disorders of anxiety vary in severity to a wide extent, and obsessive-compulsive disorder (OCD) persists as the fourth most common form of mental illness and is reported to be associated with memory impairment, necessitating effective means of treatment.

AIM:

To study the effect of curcumin on OCD.

METHODS:

The present study includes the determination of effect of curcumin at 5 and 10 mg/kg in quinpirole (0.5 mg/kg) -induced model of OCD, memory retention and brain monoamine levels in rats.

RESULTS:

A significant improvement from the obsessive-compulsive symptoms induced by quinpirole was observed in curcumin treated rats; curcumin showed a protective effect on memory task. An increase in serotonin levels and a decrease in the dopamine levels were observed in curcumin treated rats.

CONCLUSION:

Curcumin treatment had shown a protective effect in OCD with considerable influence on brain monoamine levels, thus providing an evidence for the predictive and construct validity of the model.

KEYWORDS:

Obsessive-compulsive disorder, curcumin, dopamine, quinpirole, serotonin, water maze apparatus

PMID:
22624119
[PubMed]
PMCID:
PMC3354439
Free PMC Article

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