Display Settings:

Format

Send to:

Choose Destination
See comment in PubMed Commons below
J Cell Commun Signal. 2012 Aug;6(3):139-53. doi: 10.1007/s12079-012-0165-3. Epub 2012 May 24.

Molecular mechanisms underlying the fetal programming of adult disease.

Author information

  • 1The Department of Physiology & Pharmacology, University of Western Ontario, London, Ontario, Canada, N6A 5C1.

Abstract

Adverse events in utero can be critical in determining quality of life and overall health. It is estimated that up to 50 % of metabolic syndrome diseases can be linked to an adverse fetal environment. However, the mechanisms linking impaired fetal development to these adult diseases remain elusive. This review uncovers some of the molecular mechanisms underlying how normal physiology may be impaired in fetal and postnatal life due to maternal insults in pregnancy. By understanding the mechanisms, which include epigenetic, transcriptional, endoplasmic reticulum (ER) stress, and reactive oxygen species (ROS), we also highlight how intervention in fetal and neonatal life may be able to prevent these diseases long-term.

PMID:
22623025
[PubMed]
PMCID:
PMC3421023
Free PMC Article
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Icon for Springer Icon for PubMed Central
    Loading ...
    Write to the Help Desk