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Oxid Med Cell Longev. 2012;2012:163913. doi: 10.1155/2012/163913. Epub 2012 Apr 26.

The bad, the good, and the ugly about oxidative stress.

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  • 1School of Medicine, Medical Research Institute, Neuroscience Research Group, University of Antioquia (UdeA), SIU, Calle 62 # 52-59, Building 1, Room 412, Medellin 1226, Colombia. marlene.jimenez@neurociencias.udea.edu.co

Abstract

Alzheimer's disease (AD), Parkinson's disease (PD), and cancer (e.g., leukemia) are the most devastating disorders affecting millions of people worldwide. Except for some kind of cancers, no effective and/or definitive therapeutic treatment aimed to reduce or to retard the clinic and pathologic symptoms induced by AD and PD is presently available. Therefore, it is urgently needed to understand the molecular basis of these disorders. Since oxidative stress (OS) is an important etiologic factor of the pathologic process of AD, PD, and cancer, understanding how intracellular signaling pathways respond to OS will have a significant implication in the therapy of these diseases. Here, we propose a model of minimal completeness of cell death signaling induced by OS as a mechanistic explanation of neuronal and cancer cell demise. This mechanism might provide the basis for therapeutic design strategies. Finally, we will attempt to associate PD, cancer, and OS. This paper critically analyzes the evidence that support the "oxidative stress model" in neurodegeneration and cancer.

PMID:
22619696
[PubMed - indexed for MEDLINE]
PMCID:
PMC3350994
Free PMC Article
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