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Biochem Soc Trans. 2012 Jun 1;40(3):555-60. doi: 10.1042/BST20120084.

Thiamin biosynthesis: still yielding fascinating biological chemistry.

Author information

  • 1Department of Chemistry, Texas A&M University, College Station, TX 77843, U.S.A. Begley@chem.tamu.edu

Abstract

The present paper describes the biosynthesis of the thiamin thiazole in Bacillus subtilis and Saccharomyces cerevisiae. The two pathways are quite different: in B. subtilis, the thiazole is formed by an oxidative condensation of glycine, deoxy-D-xylulose 5-phosphate and a protein thiocarboxylate, whereas, in S. cerevisiae, the thiazole is assembled from glycine, NAD and Cys205 of the thiazole synthase.

PMID:
22616866
[PubMed - indexed for MEDLINE]
PMCID:
PMC3771315
Free PMC Article

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