Thiamin biosynthesis: still yielding fascinating biological chemistry

Biochem Soc Trans. 2012 Jun 1;40(3):555-60. doi: 10.1042/BST20120084.

Abstract

The present paper describes the biosynthesis of the thiamin thiazole in Bacillus subtilis and Saccharomyces cerevisiae. The two pathways are quite different: in B. subtilis, the thiazole is formed by an oxidative condensation of glycine, deoxy-D-xylulose 5-phosphate and a protein thiocarboxylate, whereas, in S. cerevisiae, the thiazole is assembled from glycine, NAD and Cys205 of the thiazole synthase.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Bacillus subtilis / metabolism*
  • Biosynthetic Pathways
  • Isomerases / metabolism
  • Saccharomyces cerevisiae / metabolism*
  • Sulfides / metabolism
  • Thiamine / biosynthesis*
  • Thiamine / chemistry

Substances

  • Sulfides
  • Isomerases
  • Thiamine