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Fetal Diagn Ther. 2012;31(4):221-9. doi: 10.1159/000337322. Epub 2012 May 17.

A mixture model of ductus venosus pulsatility index in screening for aneuploidies at 11-13 weeks' gestation.

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  • 1Fetal Medicine Unit, Obstetrics and Gynecology Department, Cruces University Hospital, Biscay, Spain.



To assess the value of ductus venosus pulsatility index for veins (DV PIV) in screening for aneuploidies at 11-13 weeks' gestation.


Fetal DV PIV was measured in singleton pregnancies undergoing first-trimester screening for aneuploidies. In euploid (n = 44,756) and aneuploid (202 cases of trisomy 21, 72 cases of trisomy 18 and 30 cases of trisomy 13) fetuses, DV PIV was best described by a mixture model of distributions. Performance of screening for aneuploidies by DV PIV alone and in combination with fetal nuchal translucency (NT) thickness and serum free β-hCG and PAPP-A was estimated.


In euploid pregnancies there was a bimodal distribution of DV PIV with a dominant crown-rump length (CRL)-dependent part, accounting for around 97% of cases in Caucasians and around 93% in Afro-Caribbeans, and a smaller CRL-independent distribution. In aneuploidies the dominant part was the CRL-independent distribution, which accounted for around 85% cases of trisomies 21 and 18 and 70% of cases of trisomy 13. In screening for trisomy 21 by maternal age, NT and biochemistry at a risk cutoff of 1 in 100, the detection rate was 89.7% and false positive rate was 2.74%; with addition of DV PIV, the values were 93.5 and 1.63%, respectively.


Measurement of DV PIV improves the performance of first-trimester combined test for aneuploidies.

Copyright © 2012 S. Karger AG, Basel.

[PubMed - indexed for MEDLINE]
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