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Trends Pharmacol Sci. 2012 Jul;33(7):382-93. doi: 10.1016/j.tips.2012.04.003. Epub 2012 May 19.

Crosstalk between TGF-β signaling and the microRNA machinery.

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  • 12nd Department of Medicine, Faculty of Medicine, Semmelweis University, Budapest, Hungary.

Abstract

The activin/transforming growth factor-β (TGF-β) pathway plays an important role in tumorigenesis either by its tumor suppressor or tumor promoting effect. Loss of members of the TGF-β signaling by somatic mutations or epigenetic events, such as DNA methylation or regulation by microRNA (miRNA), may affect the signaling process. Most members of the TGF-β pathway are known to be targeted by one or more miRNAs. In addition, the biogenesis of miRNAs is also regulated by TGF-β both directly and through SMADs. Based on these interactions, it appears that autoregulatory feedback loops between TGF-β and miRNAs influence the fate of tumor cells. Our aim is to review the crosstalk between TGF-β signaling and the miRNA machinery to highlight potential novel therapeutic targets.

Copyright © 2012 Elsevier Ltd. All rights reserved.

PMID:
22613783
[PubMed - indexed for MEDLINE]
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