Format

Send to:

Choose Destination
See comment in PubMed Commons below
Fertil Steril. 2012 Jul;98(1):109-16. doi: 10.1016/j.fertnstert.2012.04.012. Epub 2012 May 16.

Body mass index and short-term weight change in relation to treatment outcomes in women undergoing assisted reproduction.

Author information

  • 1Department of Nutrition, Harvard School of Public Health, Boston, Massachusetts 02115, USA. jchavarr@hsph.harvard.edu

Abstract

OBJECTIVE:

To assess the relation between body mass index (BMI) and short-term weight change with assisted reproductive technology (ART) outcomes.

DESIGN:

Prospective cohort study.

SETTING:

Fertility center.

PATIENT(S):

A total of 170 women undergoing 233 ART cycles.

INTERVENTION(S):

Baseline BMI and short-term weight change were related to ART outcomes. Regression models accounting for repeated observations were used to adjust data for potential confounders.

MAIN OUTCOME MEASURE(S):

Peak E2 levels, oocyte yield, MII yield, fertilization rate, embryo quality, postive [beta]-hCH, clinical pregnancy and live birth rates.

RESULT(S):

Overweight and obesity were associated with lower live birth rates. The adjusted live birth rate (95% confidence interval) was 42% (28%-58%) among women with a BMI between 20 and 22.4 kg/m(2) and 23% (14%-36%) among overweight or obese women. Short-term weight loss was associated with a higher proportion of metaphase II (MII) oocytes retrieved. The adjusted proportion of MII eggs was 91% (87%-94%) for women who lost 3 kg or more and 86% (81%-89%) for women whose weight remained stable. This association was stronger among women who were overweight or obese at baseline. Short-term weight loss was unrelated to positive β-hCG, clinical pregnancy, or live birth rates.

CONCLUSION(S):

Overweight and obesity were related to lower live birth rates in women undergoing ART. Short-term weight loss was related to higher MII yield, particularly among overweight and obese women, but unrelated to clinical outcomes.

Copyright © 2012 American Society for Reproductive Medicine. Published by Elsevier Inc. All rights reserved.

PMID:
22607889
[PubMed - indexed for MEDLINE]
PMCID:
PMC3389169
Free PMC Article
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Elsevier Science Icon for PubMed Central
    Loading ...
    Write to the Help Desk