-
- Comment in:
-
Nature. 1990 Dec 20-27;348(6303):674-5.
A gene in the human major histocompatibility complex class II region controlling the class I antigen presentation pathway.
Division of Tumor Virology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts 02115.
Major histocompatibility complex (MHC) class I molecules export peptides to the cell surface for surveillance by cytotoxic T lymphocytes. Intracellular peptide binding is critical for the proper assembly and transport of class I molecules. This mechanism is impaired as a result of a non-functional peptide supply factor gene (PSF) in several human mutant cell lines with genomic lesions in the MHC. We have now identified PSF in the MHC class II region by deletion mapping in mutants and chromosome-walking. PSF is homologous to mammalian and bacterial ATP-dependent transport proteins, suggesting that it operates in the intracellular transport of peptides.
PMID: 2259384 [PubMed - indexed for MEDLINE]
-
Cited by 92 PubMed Central articles
-
Genetic susceptibility to type 1 diabetes in the intracellular pathway of antigen processing - a subject review and cross-study comparison.
Sia C, Weinem M.
Rev Diabet Stud. 2005 Spring; 2(1):40-52. Epub 2005 May 10.
[Rev Diabet Stud. 2005]
-
ATP-binding cassette transporters are required for efficient RNA interference in Caenorhabditis elegans.
Sundaram P, Echalier B, Han W, Hull D, Timmons L.
Mol Biol Cell. 2006 Aug; 17(8):3678-88. Epub 2006 May 24.
[Mol Biol Cell. 2006]
-
ReviewThe continuing challenges of leprosy.
Scollard DM, Adams LB, Gillis TP, Krahenbuhl JL, Truman RW, Williams DL.
Clin Microbiol Rev. 2006 Apr; 19(2):338-81.
[Clin Microbiol Rev. 2006]
- » See all...