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Bioessays. 2012 Aug;34(8):643-7. doi: 10.1002/bies.201200033. Epub 2012 May 16.

The evolution of dynamin to regulate clathrin-mediated endocytosis: speculations on the evolutionarily late appearance of dynamin relative to clathrin-mediated endocytosis.

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  • 1Department of Cell Biology, The Scripps Research Institute, La Jolla, CA, USA.


Whereas clathrin-mediated endocytosis (CME) exists in all eukaryotic cells, we first detect classical dynamin in Ichthyosporid, a single-cell, metazoan precursor. Based on a key functional residue in its pleckstrin homology domain, we speculate that the evolution of metazoan dynamin coincided with the specialized need for regulated CME during neurotransmission.

Copyright © 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

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