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Department of Cell Biology, The Scripps Research Institute, La Jolla, CA, USA.
Whereas clathrin-mediated endocytosis (CME) exists in all eukaryotic cells, we first detect classical dynamin in Ichthyosporid, a single-cell, metazoan precursor. Based on a key functional residue in its pleckstrin homology domain, we speculate that the evolution of metazoan dynamin coincided with the specialized need for regulated CME during neurotransmission.
Copyright © 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
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