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Mol Biosyst. 2012 Aug;8(8):2023-35, 2014. doi: 10.1039/c2mb25067e. Epub 2012 May 16.

Galvestine-1, a novel chemical probe for the study of the glycerolipid homeostasis system in plant cells.

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  • 1Laboratoire de Physiologie Cellulaire Végétale, UMR 5168 CNRS-CEA-INRA-Université J. Fourier Grenoble 1, Grenoble, France.


Plant cells are characterized by the presence of chloroplasts, membrane lipids of which contain up to ∼80% mono- and digalactosyldiacylglycerol (MGDG and DGDG). The synthesis of MGDG in the chloroplast envelope is essential for the biogenesis and function of photosynthetic membranes, is coordinated with lipid metabolism in other cell compartments and is regulated in response to environmental factors. Phenotypic analyses of Arabidopsis using the recently developed specific inhibitor called galvestine-1 complete previous analyses performed using various approaches, from enzymology, cell biology to genetics. This review details how this probe could be beneficial to study the lipid homeostasis system at the whole cell level and highlights connections between MGDG synthesis and Arabidopsis flower development.

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