Abstract
Glutoxim and molixan belong to new generation of disulfide-containing drugs with immunomodulatory, hepatoprotective and hemopoetic effect on cells. Using Fura-2AM microfluorimetry, two structurally distinct actin filament disrupters, latrunculin B and cytochalasin D, and calyculin A, which causes actin filaments condensation under plasmalemma, we have shown the involvement of actin cytoskeleton in the intracellular Ca(2+)-concentration increase induced by glutoxim or molixan in rat peritoneal macrophages. Morphological data obtained with the use of rhodamine-phalloidine have demonstrated that glutoxim and molixan cause the actin cytoskeleton reorganization in rat peritoneal macrophages.
MeSH terms
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Actin Cytoskeleton / drug effects
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Actin Cytoskeleton / physiology*
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Actin Cytoskeleton / ultrastructure
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Animals
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Bridged Bicyclo Compounds, Heterocyclic / pharmacology
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Calcium / metabolism*
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Calcium Signaling / physiology*
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Cytochalasin D / pharmacology
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Cytoprotection
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Drug Combinations
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Immunologic Factors / pharmacology
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Inosine / pharmacology*
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Macrophages, Peritoneal / drug effects*
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Macrophages, Peritoneal / physiology
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Macrophages, Peritoneal / ultrastructure
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Marine Toxins
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Microscopy, Fluorescence
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Oligopeptides / pharmacology*
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Oxazoles / pharmacology
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Phalloidine / analogs & derivatives
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Rats
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Rats, Wistar
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Rhodamines
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Thiazolidines / pharmacology
Substances
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Bridged Bicyclo Compounds, Heterocyclic
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Drug Combinations
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Immunologic Factors
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Marine Toxins
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Oligopeptides
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Oxazoles
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Rhodamines
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Thiazolidines
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glutoxim
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inosine glycyl-cysteinyl-glutamate disodium
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rhodamine-phalloidin
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Phalloidine
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Cytochalasin D
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Inosine
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calyculin A
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latrunculin B
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Calcium