Chem Asian J. 2012 Aug;7(8):1881-6. doi: 10.1002/asia.201200166. Epub 2012 May 15.

Simple analogues of qinghaosu (artemisinin).

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State Key Laboratory of Bioorganic and Natural Products Chemistry, Shanghai Institution of Organic Chemistry, Chinese Academy of Sciences, 345 Lingling Road, Shanghai 200032, China.

Abstract

A series of 1,2,4-trioxanes were synthesized in which the key peroxy bonds were installed through a molybdenum-catalyzed perhydrolysis of the epoxy rings. A core structure was identified that may serve as a promising lead structure for further investigations because of its high antimalarial activity (comparable to that of artesunate and chloroquine), apparent potential for scale-up and derivatization, and facile monitoring/tracing by using UV light.

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Simple analogues of qinghaosu (artemisinin).
Simple analogues of qinghaosu (artemisinin).
Chem Asian J. 2012 Aug ;7(8):1881-6. doi: 10.1002/asia.201200166. Epub 2012 May 15 .

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