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J Theor Biol. 2012 Aug 21;307:37-41. doi: 10.1016/j.jtbi.2012.05.002. Epub 2012 May 12.

A molecular network underlying spontaneous cAMP oscillation and synchronization in Dictyostelium.

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  • 1Life Science Production Div., NOF Corporation, 5-10 Tokodai, Tsukuba 300-2635, Japan.


We propose a molecular network, incorporating both adaptation and phosphorylation, to account for the spontaneous cAMP oscillation of Dictyostelium discoideum. We have modified the scheme previously proposed by Loomis and his collaborators so as to include adaptation by the cAMP receptor and such that extracellular cAMP is formed by the secreted intracellular cAMP instead of being directly produced by adenylyl cyclase. Furthermore, our scheme provides better robustness, and can be applied to spontaneous cAMP production by a cluster of cells.

Copyright © 2012 Elsevier Ltd. All rights reserved.

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