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Cancer Discov. 2011 Oct;1(5):381-2. doi: 10.1158/2159-8290.CD-11-0228.

Nuclear receptor LXR as a novel therapeutic antitumoral target in glioblastoma.

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  • 1Laboratory of Lipid Metabolism and Cancer, Department of Translational Pharmacology, Consorzio Mario Negri Sud, Santa Maria Imbaro, Bari, Italy.


Both primary and transformed cells need cholesterol for their growth. Guo and colleagues unraveled the connection between epidermal growth factor receptor mutations in glioblastoma and increased cholesterol influx via sterol regulatory element-binding protein 1 and low-density lipoprotein receptor (LDLR) increase. They propose the activation of the liver X receptor-inducible degrader of LDLR-LDLR axis as a therapeutic approach to reduce intracellular cholesterol, block tumor growth, and induce cell death.

©2011 AACR.

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