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Cancer Discov. 2011 Aug;1(3):203-4. doi: 10.1158/2159-8290.CD-11-0157.

mTOR inhibition, the second generation: ATP-competitive mTOR inhibitor initiates unexpected receptor tyrosine kinase-driven feedback loop.

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  • 1Institute for Cancer Genetics and Herbert Irving Comprehensive Cancer Center, Columbia University, New York, New York 10032, USA.

Abstract

mTOR inhibition with the ATP-competitive kinase inhibitor AZD8055 induces receptor tyrosine kinase-dependent feedback activation of AKT.

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PMID:
22586570
[PubMed - indexed for MEDLINE]
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