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FEBS Lett. 2012 Jul 16;586(15):2097-105. doi: 10.1016/j.febslet.2012.04.061. Epub 2012 May 11.

Protein translocation as a tool: The current rapamycin story.

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  • 1Cell Biology and Biophysics Unit, EMBL Heidelberg, 69117 Heidelberg, Germany.

Abstract

In cell biology and pharmacology, small chemicals are mostly used as agonists and antagonists against receptors and enzymes. The immunosuppressant rapamycin can serve an entirely different purpose: if employed sensibly, it might function as an inducer of dimerization that is able to rapidly activate enzyme activity inside the intact cell. A number of very recent developments such as photoactivatable derivatives make rapamycin an even more attractive tool for basic science.

Copyright © 2012 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.

PMID:
22584056
[PubMed - indexed for MEDLINE]
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