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Circ Res. 2012 May 11;110(10):1364-90. doi: 10.1161/CIRCRESAHA.111.243972.

Biochemistry, physiology, and pathophysiology of NADPH oxidases in the cardiovascular system.

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  • 1Division of Cardiology, Department of Medicine, Emory University, Atlanta, GA 30322, USA.

Abstract

The NADPH oxidase (Nox) enzymes are critical mediators of cardiovascular physiology and pathophysiology. These proteins are expressed in virtually all cardiovascular cells, and regulate such diverse functions as differentiation, proliferation, apoptosis, senescence, inflammatory responses and oxygen sensing. They target a number of important signaling molecules, including kinases, phosphatases, transcription factors, ion channels, and proteins that regulate the cytoskeleton. Nox enzymes have been implicated in many different cardiovascular pathologies: atherosclerosis, hypertension, cardiac hypertrophy and remodeling, angiogenesis and collateral formation, stroke, and heart failure. In this review, we discuss in detail the biochemistry of Nox enzymes expressed in the cardiovascular system (Nox1, 2, 4, and 5), their roles in cardiovascular cell biology, and their contributions to disease development.

PMID:
22581922
[PubMed - indexed for MEDLINE]
PMCID:
PMC3365576
Free PMC Article
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