Abstract
A new series of diazadioxa oxovanadium(IV) macrocyclic complexes of type [VO(mac)]SO(4) have been synthesized via the condensation reaction of a 3-(phenyl/substituted phenyl)-4-amino-5-hydrazino-1,2,4-triazole (H(2)L) with salicylaldehyde/2-hydroxyacetophenone and 1,4-dibromobutane in the presence of oxovanadium(IV) sulfate in ethanol. All the newly synthesized compounds were characterized on the basis of elemental analyses, conductance measurements, magnetic properties, spectral (UV-Vis, IR, EPR) and XRD studies. The particle size of the complexes has been calculated from XRD spectra using Debye-Scherrer formula and these are found to be in 31-32 nm range. The efficacy of two macrocyclic complexes was also studied in streptozotocin-induced diabetic rats over a period of 30 days. The administration of these complexes in diabetic rats reversed the diabetic effect due to their insulin-mimetic effects.
Copyright © 2012 Elsevier B.V. All rights reserved.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Blood Glucose / metabolism
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Blood Proteins / metabolism
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Body Weight / drug effects
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Cholesterol / blood
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Coordination Complexes / chemical synthesis
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Coordination Complexes / chemistry
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Coordination Complexes / pharmacology*
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Creatinine / blood
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Dioxanes / chemical synthesis
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Dioxanes / chemistry
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Dioxanes / pharmacology*
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Electron Spin Resonance Spectroscopy
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Electrons
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Glucose Tolerance Test
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Hemoglobins / metabolism
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Insulin / pharmacology*
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Macrocyclic Compounds / chemical synthesis
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Macrocyclic Compounds / chemistry
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Macrocyclic Compounds / pharmacology*
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Male
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Nitrogen Dioxide / chemistry*
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Rats
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Rats, Wistar
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Spectrophotometry, Infrared
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Urea / blood
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Vanadates / chemistry
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Vanadates / pharmacology*
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X-Ray Diffraction
Substances
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Blood Glucose
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Blood Proteins
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Coordination Complexes
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Dioxanes
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Hemoglobins
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Insulin
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Macrocyclic Compounds
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oxovanadium IV
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Vanadates
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Urea
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Cholesterol
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Creatinine
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Nitrogen Dioxide