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Cell. 2012 May 11;149(4):735-7. doi: 10.1016/j.cell.2012.04.015.

EGFR in limbo.

Author information

  • 1Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA 02215, USA. eck@red.dfci.harvard.edu


The epidermal growth factor receptor (EGFR) is normally activated by ligand-induced dimerization. Oncogenic mutations in EGFR promote activation in a largely ligand-independent manner. Shan et al. uncover a partially disordered state of EGFR kinase, providing evidence that oncogenic mutations counteract this intrinsic structural instability to promote dimerization and aberrant activation.

Copyright © 2012 Elsevier Inc. All rights reserved.

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