Send to:

Choose Destination
See comment in PubMed Commons below
Cell. 2012 May 11;149(4):735-7. doi: 10.1016/j.cell.2012.04.015.

EGFR in limbo.

Author information

  • 1Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA 02215, USA.


The epidermal growth factor receptor (EGFR) is normally activated by ligand-induced dimerization. Oncogenic mutations in EGFR promote activation in a largely ligand-independent manner. Shan et al. uncover a partially disordered state of EGFR kinase, providing evidence that oncogenic mutations counteract this intrinsic structural instability to promote dimerization and aberrant activation.

Copyright © 2012 Elsevier Inc. All rights reserved.

Free full text
PubMed Commons home

PubMed Commons

How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Elsevier Science
    Loading ...
    Write to the Help Desk