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Ann Dermatol. 2012 May;24(2):144-50. doi: 10.5021/ad.2012.24.2.144. Epub 2012 Apr 26.

A randomized, open-label, multicenter trial of topical tacrolimus for the treatment of pruritis in patients with atopic dermatitis.

Author information

  • 1Department of Dermatology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan. takeuchs@dermatol.med.kyushu-u.ac.jp

Abstract

BACKGROUND:

Pruritis caused by atopic dermatitis (AD) is not always well controlled by topical corticosteroid therapy, but use of tacrolimus often helps to soothe such intractable pruritis in clinical settings.

OBJECTIVE:

To determine the anti-pruritic efficacy of topical tacrolimus in treating AD in induction and maintenance therapy.

METHODS:

Prior to the study, patients were randomly allocated into two groups, induction therapy followed by tacrolimus monotherapy maintenance, and induction therapy followed by emollient-only maintenance. In the induction therapy, the patients were allowed to use topical tacrolimus and emollients in addition to a low dose (<10 g/week) of topical steroids. Patients showing relief from pruritis were allowed to proceed to maintenance therapy. Recurrence of pruritis in maintenance therapy was examined as a major endpoint.

RESULTS:

Two-thirds of patients (44/68; 64.7%) showed relief from pruritis after induction therapy. Pruritis recurred in 23.8% (5/21) of the tacrolimus monotherapy group and in 100% (21/21) of the emollient group during maintenance period, a difference that was statistically significant.

CONCLUSION:

Use of topical tacrolimus is effective in controlling pruritis of AD compared to emollient.

KEYWORDS:

Atopic dermatitis; Maintenance therapy; Pruritis; Randomized trial; Tacrolimus

PMID:
22577263
[PubMed]
PMCID:
PMC3346903
Free PMC Article

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