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Ann Epidemiol. 2012 Jul;22(7):466-73. doi: 10.1016/j.annepidem.2012.04.007. Epub 2012 May 9.

Lean tissue mass wasting is associated with increased risk of mortality among women with pulmonary tuberculosis in urban Uganda.

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  • 1Department of Paediatrics & Child Health, College of Health Sciences, Makerere University Kampala, Uganda. mupez@yahoo.com

Abstract

OBJECTIVES:

We assessed the impact of wasting on survival in patients with tuberculosis by using a precise height-normalized lean tissue mass index (LMI) estimated by bioelectrical impedance analysis and body mass index (BMI).

METHODS:

In a retrospective cohort study, 747 adult pulmonary patients with tuberculosis who were screened for HIV and nutritional status were followed for survival.

RESULTS:

Of 747 patients, 310 had baseline wasting by BMI (kg/m(2)) and 103 by LMI (kg/m(2)). Total deaths were 105. Among men with reduced BMI, risk of death was 70% greater (hazard ratio [HR] 1.7, 95% confidence interval [95% CI] 1.03-2.81) than in men with normal BMI. Survival did not differ by LMI among men (HR 1.1; 95% CI 0.5-2.9). In women, both the BMI and LMI were associated with survival. Among women with reduced BMI, risk of death was 80% greater (HR 1.8; 95% CI 0.9-3.5) than in women with normal BMI; risk of death was 5-fold greater (HR 5.0; 95% CI 1.6-15.9) for women with low LMI compared with women with normal LMI.

CONCLUSIONS:

Wasting assessed by reduced BMI is associated with an increased risk for death among both men and women whereas reduced LMI is among women with tuberculosis.

Copyright © 2012 Elsevier Inc. All rights reserved.

PMID:
22575813
[PubMed - indexed for MEDLINE]
PMCID:
PMC3377556
Free PMC Article
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