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Nat Prod Commun. 2012 Apr;7(4):427-30.

Culcitiolides A-D, four new eremophilane-type sesquiterpene derivatives from Senecio culcitioides.

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  • 1Department of Biological Chemistry, Faculty of Science, Okayama University of Science, Okayama 700-0005, Japan.


Four new eremophilane-type sesquiterpenes, culcitiolides A-D, were isolated from the stem of Senecio culcitioides Sch. Bip (Asteraceae). Their structures were established by detailed 2D NMR spectroscopic and single-crystal X-ray experiments. These compounds were assessed for inhibitory activity against nuclear factor kappaB (NF-kappaB). Culcitiolides C and D at 20 microM showed 97 and 100% inhibition of NF-kappaB activity, respectively.

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