Format

Send to

Choose Destination
See comment in PubMed Commons below
Org Biomol Chem. 2012 Jun 21;10(23):4496-9. doi: 10.1039/c2ob25440a. Epub 2012 May 9.

Strategy for catch and release of azide-tagged biomolecules utilizing a photolabile strained alkyne construct.

Author information

  • 1Institute of Organic Chemistry, University of Tübingen, Auf der Morgenstelle 18, 72076 Tübingen, Germany.

Abstract

A photolabile o-nitrobenzyl linker-cyclooctyne conjugate was prepared, immobilized on poly(methacrylate) beads and utilized as a trap for azide-functionalized compounds. These could be released by 365 nm UV light irradiation in high yield and purity. The "reagent-free" and time economic catch and release protocol was deemed useful for chemical proteomics applications.

[PubMed - indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Royal Society of Chemistry
    Loading ...
    Write to the Help Desk