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Org Biomol Chem. 2012 Jun 21;10(23):4496-9. doi: 10.1039/c2ob25440a. Epub 2012 May 9.

Strategy for catch and release of azide-tagged biomolecules utilizing a photolabile strained alkyne construct.

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  • 1Institute of Organic Chemistry, University of Tübingen, Auf der Morgenstelle 18, 72076 Tübingen, Germany.


A photolabile o-nitrobenzyl linker-cyclooctyne conjugate was prepared, immobilized on poly(methacrylate) beads and utilized as a trap for azide-functionalized compounds. These could be released by 365 nm UV light irradiation in high yield and purity. The "reagent-free" and time economic catch and release protocol was deemed useful for chemical proteomics applications.

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