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Gut Liver. 2012 Apr;6(2):256-61. doi: 10.5009/gnl.2012.6.2.256. Epub 2012 Apr 17.

The use of gabexate mesylate and ulinastatin for the prevention of post-endoscopic retrograde cholangiopancreatography pancreatitis.

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  • 1Gastroenterology and Hepatobiliary Center, Department of Internal Medicine, Cheongju St. Mary's Hospital, Cheongju, Korea.

Abstract

BACKGROUND/AIMS:

Acute pancreatitis is a common complication of endoscopic retrograde cholangiopancreatography (ERCP). Only a few pharmacologic agents have been shown to have potential efficacy for the prophylactic treatment of post-ERCP pancreatitis (PEP). The aim of this study was to determine whether prophylactic gabexate and ulinastatin can decrease the incidence of PEP.

METHODS:

From January 2005 to April 2010, 1,679 patients undergoing ERCP treatment were consecutively enrolled in the study. After selective exclusion, a total of 1,480 patients were included in the analysis. The patients were separated into 3 groups according to the prophylactic administration of gabexate (593 patients), ulinastatin (229 patients), or saline solution (658 patients) and analyzed retrospectively. The primary outcome measurements were the incidence of pancreatitis and hyperamylasemia.

RESULTS:

PEP occurred in 21 of the 593 (3.5%) patients who received gabexate, 16 of the 229 (7.0%) patients who received ulinastatin, and 48 of the 658 (7.3%) patients who received a saline solution. The incidence of PEP was significantly different between the gabexate and ulinastatin or saline solution groups (p<0.05).

CONCLUSIONS:

Gabexate prophylaxis is effective in preventing PEP. However, there is no difference in the beneficial effects of the prophylactic administration of ulinastatin and a saline solution.

KEYWORDS:

Endoscopic retrograde cholangiopancreatography; Gabexate; Pancreatitis; Ulinastatin

PMID:
22570757
[PubMed]
PMCID:
PMC3343166
Free PMC Article

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