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Genet Res Int. 2011;2011:652461. doi: 10.4061/2011/652461. Epub 2011 Oct 5.

Transcriptional elongation and mRNA export are coregulated processes.

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  • 1Centro de Investigación Príncipe Felipe (CIPF), Avenida Saler, 16. 46012, Valencia, Spain.

Abstract

Chromatin structure complexity requires the interaction and coordinated work of a multiplicity of factors at different transcriptional regulation stages. Transcription control comprises a set of processes that ensures proper balance in the gene expression under different conditions, such as signals, metabolic states, or development. We could frame those steps from epigenetic marks to mRNA stability to support the holistic view of a fine-tune balance of final mRNA levels through mRNA transcription, export, stability, translation, and degradation. Transport of mRNA from the nucleus to the cytoplasm is a key process in regulated gene expression. Transcriptional elongation and mRNA export are coregulated steps that determine the mature mRNA levels in the cytoplasm. In this paper, recent insights into the coordination of these processes in eukaryotes will be summarised.

PMID:
22567364
[PubMed]
PMCID:
PMC3335577
Free PMC Article

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