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Front Immunol. 2012 Jan 11;2:94. doi: 10.3389/fimmu.2011.00094. eCollection 2011.

Decay kinetics of HIV-1 specific T cell responses in vertically HIV-1 exposed seronegative infants.

Author information

  • 1Division of Experimental Medicine, Department of Medicine, San Francisco General Hospital, University of California San Francisco San Francisco, CA, USA.

Abstract

OBJECTIVE:

The majority of infants born, in developed countries, to HIV-1 positive women are exposed to the HIV-1 virus in utero or peri/post-partum, but are born uninfected. We, and others, have previously shown HIV-1 specific T cell responses in HIV-1 exposed seronegative (HESN) neonates/infants. Our objective in this study was to examine the rate of decay in their HIV-1 specific T cell response over time from birth.

DESIGN:

Cross-sectional and longitudinal studies of HIV-1 specific T cell responses in HESN infants were performed.

METHODS:

Peripheral blood mononuclear cells (PBMC) were isolated from 18 HIV-1 DNA PCR negative infants born to HIV-1 infected mothers receiving care at the Jacobi Medical Center, Bronx, NY, USA. PBMC were examined for T cell responses to HIV-1 antigens by interferon-gamma (IFN-γ) ELISPOT.

RESULTS:

PBMC from 15 HESN neonates/infants were analyzed. We observed a decay of HIV-1 specific T cell responses from birth at a rate of -0.599 spot forming unit/10⁶ cells per day, with a median half-life decay rate of 21.38 weeks (13.39-115.8).

CONCLUSION:

Our results support the dynamic nature of T cell immunity in the context of a developing immune system. The disparate rate of decay with studies of adults placed on antiretroviral drugs suggests that antigen specific T cell responses are driven by the natural rate of decay of the T cell sub-populations themselves.

KEYWORDS:

HIV-1; T cells; exposed seronegative; neonates; vertically exposed

PMID:
22566883
[PubMed]
PMCID:
PMC3341962
Free PMC Article
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