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Neuropharmacology. 2013 Mar;66:1-11. doi: 10.1016/j.neuropharm.2012.04.009. Epub 2012 Apr 28.

mGlu3 receptor and astrocytes: partners in neuroprotection.

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  • 1Instituto de Investigaciones Biom√©dicas (INBIOMED), School of Medicine, University of Buenos Aires, Paraguay 2155 Piso 10, CABA 1121 Buenos Aires, Argentina. ddurand@fmed.uba.ar

Abstract

Astrocytes are currently studied intensively because of their now highlighted relevance as key players with neurons that modulate a wide range of central functions, from synaptic plasticity and synaptogenesis to regulation of metabolic and neuroinflammatory processes. Since the discovery of mGlu3 receptors on astrocytes, accumulating evidence supports a role of these receptors not only in maintaining synaptic homeostasis and treating psychiatric disorders but also in promoting astrocyte survival in several pathologic conditions. This review focuses on providing up-to-date knowledge regarding effects of activating astroglial mGlu3 receptors on psychiatric disorders, astrocyte and neuronal survival, and neurodegenerative diseases. This article is part of a Special Issue entitled 'Metabotropic Glutamate Receptors'.

Copyright © 2012 Elsevier Ltd. All rights reserved.

PMID:
22564439
[PubMed - indexed for MEDLINE]
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