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Cell Stem Cell. 2012 May 4;10(5):515-9. doi: 10.1016/j.stem.2012.04.002.

Short-term calorie restriction enhances skeletal muscle stem cell function.

Author information

  • 1Department of Stem Cell and Regenerative Biology, Harvard University, Harvard Stem Cell Institute, 7 Divinity Avenue, Cambridge, MA 02138, USA.

Abstract

Calorie restriction (CR) extends life span and ameliorates age-related pathologies in most species studied, yet the mechanisms underlying these effects remain unclear. Using mouse skeletal muscle as a model, we show that CR acts in part by enhancing the function of tissue-specific stem cells. Even short-term CR significantly enhanced stem cell availability and activity in the muscle of young and old animals, in concert with an increase in mitochondrial abundance and induction of conserved metabolic and longevity regulators. Moreover, CR enhanced endogenous muscle repair and CR initiated in either donor or recipient animals improved the contribution of donor cells to regenerating muscle after transplant. These studies indicate that metabolic factors play a critical role in regulating stem cell function and that this regulation can influence the efficacy of recovery from injury and the engraftment of transplanted cells.

Copyright © 2012 Elsevier Inc. All rights reserved.

PMID:
22560075
[PubMed - indexed for MEDLINE]
PMCID:
PMC3561899
Free PMC Article

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