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Cell Stem Cell. 2012 May 4;10(5):497-503. doi: 10.1016/j.stem.2012.04.011.

NuRD and pluripotency: a complex balancing act.

Author information

  • 1Laboratory of Molecular Carcinogenesis, National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709, USA. hug4@niehs.nih.gov

Abstract

Embryonic stem cells (ESCs) are defined by two essential features--pluripotency and self-renewal--whose balance requires the concerted action of signal transduction pathways, transcription factor networks, and epigenetic regulators. Recent findings have implicated the NuRD chromatin remodeling complex in the sophisticated choreography of ESC regulatory pathways.

Copyright © 2012 Elsevier Inc. All rights reserved.

PMID:
22560073
[PubMed - indexed for MEDLINE]
PMCID:
PMC3348611
Free PMC Article

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