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Cell Stem Cell. 2012 May 4;10(5):487-9. doi: 10.1016/j.stem.2012.04.012.

Early embryos reprogram DNA methylation in two steps.

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  • 1Howard Hughes Medical Institute.


While DNA cytosine methylation is relatively stable in somatic tissues, it is highly dynamic during preimplantation development. A recent study in Nature by Meissner and colleagues (Smith et al., 2012) now reveals dramatic shifts in DNA methylation during the earliest stages of mouse embryogenesis at genome scale and base resolution.

Copyright © 2012 Elsevier Inc. All rights reserved.

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