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Cell Stem Cell. 2012 May 4;10(5):481-2. doi: 10.1016/j.stem.2012.04.015.

Restoring cell polarity: an HSC fountain of youth.

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  • 1Department of Hematology/Oncology, University Hospital Bonn, 53127 Bonn, Germany.


Until recently, aging was viewed as a fixed and irreversible process. However, in this issue of Cell Stem Cell, Florian et al. (2012) reveal a link between increased activity of the RhoGTPase Cdc42, hematopoietic stem cell polarity, and aging that can be regulated by pharmacological inhibition of Cdc42.

Copyright © 2012 Elsevier Inc. All rights reserved.

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