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EMBO Rep. 2012 Jun 29;13(7):631-7. doi: 10.1038/embor.2012.60.

SUMOylation of Blimp-1 is critical for plasma cell differentiation.

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  • 1Genomics Research Center, Academia Sinica, Taipei 115, Taiwan.

Abstract

Transcriptional repressor B lymphocyte-induced maturation protein-1 (Blimp-1) is a master regulator of plasma cell differentiation. Here we show that Blimp-1 is covalently modified by SUMO1 at lysine 816, a modification mediated by SUMO E3 ligase PIAS1. Mutation of Blimp-1 lysine 816 reduces transcriptional repression--correlating with a reduced interaction with a histone deacetylase, HDAC2--and impairs differentiation of antibody-secreting cells. Thus, the SUMO pathway critically regulates Blimp-1 function during plasma cell differentiation.

PMID:
22555612
[PubMed - indexed for MEDLINE]
PMCID:
PMC3388782
Free PMC Article
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