Format

Send to:

Choose Destination
See comment in PubMed Commons below
Nucleus. 2012 Mar 1;3(2):150-4. doi: 10.4161/nucl.19321. Epub 2012 Mar 1.

Chromatin "pre-pattern" and epigenetic modulation in the cell fate choice of liver over pancreas in the endoderm.

Author information

  • 1Institute for Regenerative Medicine, Department of Cell and Developmental Biology, University of Pennsylvania School of Medicine, Philadelphia, PA, USA.

Abstract

Understanding the basis for multipotency, whereby stem cells and other progenitors can differentiate into certain tissues and not others, provides insights into the mechanism of cell programming in development, homeostasis, and disease. We recently reported a screen of diverse chromatin marks to obtain clues about chromatin states in the multipotent embryonic endoderm. Genetic and pharmacologic tests of certain marks' function demonstrated that the relevant chromatin modifying factors modulate the fate choice for liver or pancreas induction in the endoderm. The information about chromatin states from embryonic studies can be used to predict lineage-specific developmental potential and chromatin modifiers to enhance particular cell fate transitions from stem cells.

PMID:
22555599
[PubMed - indexed for MEDLINE]
PMCID:
PMC3383570
Free PMC Article
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Landes Bioscience Icon for PubMed Central
    Loading ...
    Write to the Help Desk