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Nucleus. 2012 Mar 1;3(2):138-42. doi: 10.4161/nucl.19267. Epub 2012 Mar 1.

Repo-Man-PP1: a link between chromatin remodelling and nuclear envelope reassembly.

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  • 1Wellcome Trust Centre for Cell Biology, Institute of Cell Biology, University of Edinburgh, Edinburgh, UK.


Coordination of late mitotic events is crucial for the maintenance of genome stability and for the control of gene expression after cell division. Reversible protein phosphorylation regulates this process by de-phosphorylation of mitotic phospho-proteins in a sequential and coordinated manner: this allows an orderly sequence of events to take place during mitotic exit. We have identified Repo-Man/PP1 as a phosphatase complex that regulates temporally and spatially chromatin re-organization and nuclear envelope re-formation during anaphase-telophase.

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