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J Sci Food Agric. 2012 Dec;92(15):3002-6. doi: 10.1002/jsfa.5714. Epub 2012 Apr 30.

Ameliorative effect of α-tocopherol on monosodium glutamate-induced cardiac histological alterations and oxidative stress.

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  • 1School of Biosciences, Mahatma Gandhi University, Kottayam, Kerala, India.

Abstract

BACKGROUND:

Chronic oral intake of high doses of monosodium glutamate (MSG) causes oxidative stress. Oxidative stress plays an important role in the development of cardiac dysfunction and injury. Supplementation with α-tocopherol protects the body against oxidative stress and its related complications. This study was proposed to examine the protective effect of α-tocopherol against MSG-induced biochemical and histological alterations in blood and cardiac tissue of rats for a period of 180 days.

RESULTS:

Chronic oral administration of MSG (4 g kg(-1)) caused oxidative stress that was manifested by significant increase (P < 0.05) in malondialdehyde, conjugated dienes and by the decrease in the activities of superoxide dismutase, catalase, reduced glutathione, glutathione peroxidase and glutathione S-transferase in cardiac tissue. The significantly increased (P < 0.05) activities of aspartate transaminase, creatine phosphokinase and lactate dehydrogenase in serum suggested a cardiac functional disorder. Moreover, heart muscle fibers showed cloudy swelling, fiber separation and vascular congestion. Administration of α-tocopherol (200 mg kg(-1)) significantly (P < 0.05) attenuated the MSG-induced biochemical alterations in serum and cardiac tissue. α-Tocopherol also prevented the pathological changes in cardiac tissue when compared with the MSG-treated group.

CONCLUSION:

Our findings suggest that α-tocopherol may have a protective effect against MSG-induced cardiotoxicity, possibly through its antioxidant activity.

Copyright © 2012 Society of Chemical Industry.

PMID:
22549309
[PubMed - indexed for MEDLINE]
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