Display Settings:

Format

Send to:

Choose Destination
See comment in PubMed Commons below
Case Rep Med. 2012;2012:418672. doi: 10.1155/2012/418672. Epub 2012 Apr 3.

Novel BRAF Alteration in a Sporadic Pilocytic Astrocytoma.

Author information

  • 1Department of Pathology & Immunology, Washington University School of Medicine, St. Louis, MO 63110, USA.

Abstract

Pilocytic astrocytoma (PA) is the most frequently encountered glial tumor (glioma or astrocytoma) in children. Recent studies have identified alterations in the BRAF serine/threonine kinase gene as the likely causative mutation in these childhood brain tumors. The majority of these genetic changes involve chromosome 7q34 tandem duplication, resulting in aberrant BRAF fusion transcripts. In this paper, we describe a novel KIAA1549:BRAF fusion transcript in a sporadic PA tumor associated with increased ERK activation and review the spectrum of BRAF genetic alterations in this common pediatric low-grade central nervous system neoplasm.

PMID:
22548077
[PubMed]
PMCID:
PMC3324141
Free PMC Article

Images from this publication.See all images (1)Free text

Figure 1
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Icon for Hindawi Publishing Corporation Icon for PubMed Central
    Loading ...
    Write to the Help Desk