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Ther Adv Cardiovasc Dis. 2012 Jun;6(3):115-21. doi: 10.1177/1753944712446303. Epub 2012 Apr 30.

Therapeutic procedures for coronary vasospasm-induced polymorphic ventricular tachycardia.

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  • 1Vanderbilt University Medical Center, 905 Derby Trace, Nashville, TN 37211, USA.


Coronary vasospasm is an unusual cause of angina and myocardial ischemia, with the potential to provoke acute myocardial infarction, malignant cardiac arrhythmias, and sudden cardiac death. The diagnosis is largely clinical and requires a high index of suspicion. Provocation studies are rarely performed due to the risks of the procedure and the relatively low incidence of disease. A subset of patients does not respond to conventional medical therapy and a paucity of evidence exists to guide therapy. While generally believed a multifocal phenomenon, there have been reports of successful treatment of focal, refractory vasospasm with coronary stent implantation. Furthermore, consideration of an implantable cardioverter defibrillator is warranted when vasospasm is complicated by lethal ventricular arrhythmias.

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