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Bioorg Med Chem Lett. 2012 Jun 1;22(11):3653-5. doi: 10.1016/j.bmcl.2012.04.033. Epub 2012 Apr 13.

Synthesis of norlignans and in vitro inhibitory activity of antigen-induced degranulation.

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  • 1College of Pharmacy, Kyung Hee University, Seoul, Republic of Korea.

Abstract

The synthesis and biological evaluation of a series of novel norlignans are described. Norlignans were evaluated for their inhibitory activity on the release of β-hexosaminidase, a marker of degranulation, from RBL-2H3 cells induced by the IgE-antigen complex. The results showed that norlignans 4c and 4e potently inhibited degranulation, with IC(50) values of 18.3 and 17.9 μM, respectively.

Copyright © 2012 Elsevier Ltd. All rights reserved.

PMID:
22543029
[PubMed - indexed for MEDLINE]
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