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J Magn Reson Imaging. 2012 Aug;36(2):430-7. doi: 10.1002/jmri.23672. Epub 2012 Apr 25.

Multiparametric 3T endorectal mri after external beam radiation therapy for prostate cancer.

Author information

  • 1Department of Radiology and Biomedical Imaging, University of California, San Francisco, CA, USA. antonio.westphalen@ucsf.edu

Abstract

PURPOSE:

To determine the best combination of magnetic resonance imaging (MRI) parameters for the detection of locally recurrent prostate cancer after external beam radiation therapy.

MATERIALS AND METHODS:

Our Institutional Review Board approved this study with a waiver of informed consent. Twenty-six patients with suspected recurrence due to biochemical failure were part of this research. The MR protocol included T2-weighted, MR spectroscopy, and diffusion-weighted MRI. Transrectal ultrasound-guided biopsy was the standard of reference. We used logistic regression to model the probability of a positive outcome and generalized estimating equations to account for clustering. The diagnostic performance of imaging was described using receiver operating characteristic (ROC) curves.

RESULTS:

The area under the ROC curve of MR spectroscopic imaging (MRSI) was 83.0% (95% confidence interval [CI] = 75.5-89.1). The combination of all MR techniques did not significantly improve the performance of imaging beyond the accuracy of MRSI alone, but a trend toward improved discrimination was noted (86.9%; 95% CI = 77.6-93.4; P = 0.09).

CONCLUSION:

Incorporation of MRSI to T2-weighted and/or diffusion-weighted MRI significantly improves the assessment of patients with suspected recurrence after radiotherapy and a combined approach with all three modalities may have the best diagnostic performance.

Copyright © 2012 Wiley Periodicals, Inc.

PMID:
22535708
[PubMed - indexed for MEDLINE]
PMCID:
PMC3565567
Free PMC Article

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