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Praxis (Bern 1994). 2012 Apr 25;101(9):573-9. doi: 10.1024/1661-8157/a000918.

[Antimicrobial resistance among E. coli in urinary specimens: prevalence data from three laboratories in Zurich between 1985 and 2010].

[Article in German]

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  • 1Klinik für Infektionskrankheiten und Spitalhygiene, Universität Zürich, Universitätsspital Zürich, Zürich.


Urinary tract infections in women are common. Drug resistance among Escherichia coli, the most frequent uropathogen, has increased worldwide. In a prevalence study we investigated the local antibiotic susceptibility of this microorganism in urinary specimens of three laboratories in Zurich. Resistance rates against trimethoprim-sulfamethoxazole 2010 were 28%, 16% against quinolones and 16% against amoxicillin/clavulanic acid. Resistance prevalence for nitrofurantoin and fosfomycin were low with 3,6%, resp. 0,7%. The rate of extended-spectrum beta-lactamase-producing E. coli has rapidly increased to 4,3% in 2010. Based on this data and according to the international guidelines for the treatment of uncomplicated cystitis, therapy with trimethoprim-sulfamethoxazole and quinolones are no longer recommended. Nitrofurantoin and Fosfomycin are an appropriate choice. Microbiological testing is advised.

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