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Glycoconj J. 2013 Jan;30(1):11-22. doi: 10.1007/s10719-012-9376-3. Epub 2012 Apr 25.

Glycomics using mass spectrometry.

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  • 1Department of Parasitology, Biomolecular Mass Spectrometry Unit, Leiden University Medical Center, Albinusdreef 2, 2333ZA, Leiden, The Netherlands. M.Wuhrer@lumc.nl

Abstract

Mass spectrometry plays an increasingly important role in structural glycomics. This review provides an overview on currently used mass spectrometric approaches such as the characterization of glycans, the analysis of glycopeptides obtained by proteolytic cleavage of proteins and the analysis of glycosphingolipids. The given examples are demonstrating the application of mass spectrometry to study glycosylation changes associated with congenital disorders of glycosylation, lysosomal storage diseases, autoimmune diseases and cancer.

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